The LeafyCeuticals team has prepared a simple spray that has several remarkable effects including deeply penetrating pain-relief with nearly instantaneous effects and pleasant spicy fragrance.
The Leafyceuticals team has prepared a simple spray that has several beneficial effects. The spray contains β-caryophyllene and Humulene extracted from black pepper. Both compounds have rapid and remarkable effects as well as a pleasant spicy fragrance.
Many plants make both β-caryophyllene and Humulene including hops, black pepper and hemp. Chemists describe them as being ‘terpenes’ or ‘terpenoids’. Plants synthesize a broad array of terpenes from a building block molecule called isoprene. Plants produce thousands of terpenes for different purposes including resistance to insects, bacteria, and mold.
The literature suggests that β-caryophyllene and Humulene have several effects including:
Helping to kill or inhibit cancer cells.
Reducing inflammation and pain.
Hindering or killing some kinds of bacteria.
The structures of β-caryophyllene and Humulene are similar, and this may account for their parallel effects. However, β-caryophyllene has both a 9-carbon ring and 4-carbon ring while Humulene only has the 11-carbon ring. The 4-carbon ring is strained because carbon prefers 120 degree bond angles so four 90 degree angles stores significant energy. Humulene may be referred to as α-caryophyllene.
While CBD has a molecular weight of 314, the weights of β-caryophyllene and humulene are both 204. This smaller molecular weight means that the latter molecules can penetrate the skin much better than CBD as well as more directing acting on inflammatory processes. The smaller size enables the molecules to evaporate readily providing a distinctive fragrance.
The CB2 receptor binds both β-caryophyllene and humulene. The CB2 and CB1 receptors function as endocannabinoid receptors that mediate homeostasis (physiological equilibrium). Researchers originally believed that CBD activated CB2 receptors but found that it actually binds to the TRPV1 receptors that are activated by capsaicin.
CB2 receptors regulate cytokine release which causes inflammation. By activating CB2 receptors, β caryophyllene and humulene suppress reactive microglia behavior and neuroinflammatory conditions. Glial cells represent the first line of defense against inflammation and other insults. Activation of the CB2 receptor inhibits inflammation and restores normal microglial function to an anti-inflammatory state.
The white blood cells (lymphocytes) of the peripheral immune system express CB2 receptors. The endocannabinoid 2-AG acts as a full agonist to both CB1 and CB2 receptors. Ongoing research targets the CB2 receptor to treat pain, atherosclerosis, and osteoporosis.
Thus, while the body uses inflammatory processes as part of the healing process, the body may generate more inflammation than is needed. This excess inflammation includes swelling and other effects that cause pain. By moderating the inflammatory process, PRAILS reduces both pain and tissue damage from swelling.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035094/
β-caryophyllene sometimes gets abbreviated as “BCP”. The FDA regards BCP as a terpene and a GRAS, a Generally Recognized As Safe molecule. That mean FDA approves it to be consumed. However, as with other terpenes, the volatility of a concentrate can cause coughing if ingested. DO NOT INGEST PRAILS NOR PRAIG: both contain isopropyl alcohol. Supposedly, BCP has the distinction of being the first ‘dietary cannabinoid’. Research has revealed β-Caryophyllene to be beneficial for colitis, osteoarthritis, diabetes, anxiety, depression, liver fibrosis and Alzheimer-like disease states.
Recent studies show that BCP activates PPAR’s (peroxisome proliferator-activated receptors; pronounced pee-parrs) that function on the cell’s nuclear membrane. PPAR’s regulate metabolism and energy homeostasis.
Leafyceuticals makes BCP-containing products available in quality-controlled formulations. We invite people to use these products to address skin swelling, irritation, and pain. It is from the website and at other locations. ///